Is it as complicated as it appears to catch a bus from Guangzhou to Macau, any easy options

It is not complicated to catch a bus from Guangzhou to Macau in my opinion. You can take the buses at China Hotel, Garden Hotel, Haizhu Plaza, Yuexiu South Bus Station and other places in Guangzhou to take buses.
Besides the bus, there is no other direct ways.

Don't worry at all - if you take the bus from any of the locations Sunny mentioned, you simply show up and purchase a ticket at the bus stop. When I went to Macau the bus had a total of six people, and even if it's sold out you can just catch the next bus. So easy my boyfriend and I actually went to Macau on accident because the ticket agent heard "Macau" when I tried to say "Mong Kok"(HK). We had a great time.

Thanks Erin - you and Sunny have been a great help, it does sound easy enough, now i just can't wait to go.

Good tip be careful with the language barrier - LOL