Canton Tower & The Thirteen (13) Factories, Guangzhou

If I understand you right, you are going to spend two days in GZ, right? So I would recommend you go to the thirteen factories in the first day, and the Canton Tower the second day.
Route:
From GZ Railway Station to the Thirteen Factories: take subway line 2 from the railway station to Haizhu Square, and then transfer to line 6 to the Cultural Park. Get out from exit D, and then walk to the north east for about 500 yards to reach.

From the Thirteen Factories to Canton Tower: walk westwards to South Kangwang Road, there you can take the tourist bus line 2 to The Pearl River Di Jing Yuan Terminal, and then walk north to reach. Or you can walk to the Cultural Park Station and take subway line 6 there to Dong Shan Kou. Transfer to line 1 to West Tiyu Road, and then take line 3 to GZ Tower.

Hotels recommend:
1. near the Thirteen Factories: Holiday Inn Shifu GZ: no. 188, Dishifu Road, Liwan District.
2. Near the Canton Tower: regal Riviera Hotel GZ: no. 1, Haojing Street, Yizhou Road, Haizhu District.