What is the best and most direct route to take from Central in HK to Sheraton Dameisha Resort?

HK Central to SZ Luohu runs very frequently and takes an hour. Make sure to board the blue/East Rail Line bound for Lowu and not Lok Ma Chao. Details can be seen on the official website of HK MTR. You will need to change twice. Tip: pay for first class on the train platform with your HK Octopus card.

Luohu Train Station offers a lot of taxis and is convenient to get to the Dameisha Sheraton. Luohu is the furthest east standard boarder check point, so it's probably most convenient for you. A taxi ride will take about 30min without traffic. Avoid rush hours. The Sheraton offers a shuttle service upon inquiry. They can also hail cabs back into downtown.

Extra info: calculate enough time to cross the boarder between HK and SZ as well as back to HK. Avoid weekends and rush hour if possible.

Enjoy your stay in SZ!