Currently, the Shenzhen Airport supplies direct coach connection to Guangzhou, departing at 09:50 11:00 12:40 14:20 16:10 17:55 18:55. The terminal is the Guangzhou Dongpu Bus Station, Zhongshan Dadao, Tianhe District. The journey is abot 2 hours and 60RMB.

If you miss the bus, please take the airport shuttle bus line 1 to reach Shenzhen Railway Station in one hour. The bus fare is 20RMB and in operation round the clock. Then, you could catch an express train to arrive in Guangzhou in 70 minutes with a fare of 75RMB. You could search the train schedule at https://www.travelchinaguide.com/china-trains/

Haven't found the hotel you mentioned. Please check it~ There is also an Holiday Inn Express Luohu Shenzhen, located at 6, Guiyuan Bei Lu, Luohu District. It is supported with very convient transportation and commercial area.