Do I have to have an itinerary and accomodation booked before I apply for a visa?

Dear, what type of Macao visa you will apply for? If it's for tourism purpose, you need to have an itinerary, round-trip tickes, and accommodation arrangements. The officer need those information to judge whether to issue you a visa and decide its validity and stay duration. You can just make out a travel plan, get the tickets and hotel bookings, and then submit the visa application.