Traveling from HKIA to Canaught Rd Central Hong Kong, do I need to change MTR train in Kowloon?

Do you refer to 50 Canaught Rd Central HK? If yes, you don't need to change MTR in Kowloon. Upon landing, it is suggested to take bus no.E11 from Airport (Ground Transportation Centre) to Harbour Building, Pier Road. It takes around 65 mins with the fare of 21 HKD per person. After arriving, walk southeast around 100 yards to find the destination.