What is the easiest way to get to HK Disneyland from Grand Harbour Hotel?

Take Island Line from Fortress Hill Station to Central Station. Walk to HK Station and take Tung Chung Line to Sunny Bay Station and Disneyland Resort Line to Disneyland Resort Station, Exit A. The duration is 55 mins. And the ticket fare is 25.7 HKD per person. Afterwards, walk south around 300 yards to find the theme park.
Besides, you can purchase the entrance ticket on its official website. The online booking page has English version. Have fun!