Is there a bus from Yichang East to Zhangjiajie?

Take bus line 807 from East Railway Station to Long-distance Bus Passenger Transport Station. Then, take a bus to ZJJ. The bus departs at 16:00, and the trip takes about 6 hours. The fare is CNY 130 per person.

Or, you can take a train to ZJJ from Yichang East Railway Station. The trains depart at 00:41, 10:41, and 13:13. The trip takes 4.5 to 5 hours. You need to pay CNY 43.5 for a hard seat; CNY 89.5 for a hard sleeper; CNY 135.5 for a soft sleeper.
You can choose the way you like. :)