Whats the best way to get from Hongkong to Guiyang, Guizhou?

I am sorry that there is no direct train service. You may take an ordinary train to Guangzhou East from Hung Hom Railway Station (about 2 hours). Then, take metro line 1 from East Railway Station to Gongyuanqian Station, and tranfer to line 2 to South Railway Station. Take a bullet train to GY North (about 5 to 5.5 hours). :)