May I know the best transportation to travel from Guangzhou, Haizhu Square to Humen town?

You can take subway line 2, get off at Main Railway Station, Exit D1. Then walk northwest around 300 yards to get to Provincial Bus Station. There are several direct long-distance buses that can take you to Humen Town. The schedules are from 06:10 to 20:40 with the frequency of 30 to 40 mins.