Is there any shuttle bus running to pazhou area from Guangzhou international airport at 12.30am?

According to your arrival time, you are suggested to take airport shuttle bus line 1 to get to Aviation Ticket Office (Railway Station) first (operating till the arrival of the last flight). The duration is about 45 mins. And the ticket fare is CNY 18 per person.
Then take a taxi to your destination directly. The cab fare is CNY 60 to 90 in the night.