Best option for transfer from Guangzhou airport to Liuhua hotel.

Do you refer to the hotel that is located at the Yuexiu District?
If yes, you can take subway line 3 at the airport, and get off at Jiahe Wanggang Station. Then transfer to subway line 2 to the railway station, Exit D4. It will take around 35 mins on the way. And the ticket fare is CNY 7 per adult. After arriving, walk to your hotel directly.