Hi, i would like to know what is the fastest way from macau go to guangzhou?

You are suggested to pass the Gongbei Border to Gongbei, Zhuhai. The walk to the Zhuhai Railway Station, on the west of Gongbei Border.
From this railway station, you can find bullet trains for Guangzhou South Railway Station. From the south railway station, you can find the local subway line 2, so you can take that line train to Haizhu Square Station. Get out of the station from Exit B2 and then walk several steps to South Jiefang Road easily.