I'm staying at Jianguo hotel and will be going to macau on a Sunday. Which is the most convenient options:

Two methods are suggested.
The first one is to walk to the East Bus Station to take a direct bus for Gongbei Bus Station. Then walk to the Gongbei Border to pass to M.
The second one is to use Guangzhou subway system to reach Guangzhou South Railway Station where you can take a bullet train for Zhuhai Railway Station. Get out of the station and walk to east side to find the Gongbei Border. The bullet trains takes about one hour. From your hotel to the Guangzhou South Railway Station, the subway takes about one hour in general.

The ferry is not suggested, because the port is far from your hotel. Then second method you method is a little bit complex during the transfering. For the taxi, the fare will be so high, so it is not suggested.