May you help me on best manner to get to Orienatal Lander Hotel, Tong Mei Road, Mong KoK, kOWLOON from HK Int'l. Airport.

You can take bus A21 to reach Metropark Hotel Mongkok, Lai Chi Kok Road and then walk to reach your hotel. The fare is about 33HK$ and takes about 45 minutes.
Or take bus E21 to reach Mong Kok Police Station, Nathan Road, which takes about 75 minutes and costs about 14HK$. Upon arrival, you can walk to reach your hotel.
If you take taxi directly, the fare is around 225HK$.

Foremost thanks. Is it convenient to take bus or MTR with luggages tagging along ?. Well, one a piece with wheels , hop on off and space on bus / MTR ? tks.

BTW, also how far to walk from Metropark Hotel ( and Mong Kok police station ) to Oriental Lander Hotel, Tong Mei Road, and which better ? Thanks.

Yes, it is very easy, so please do not worry about it.
To reach your hotel, there is about 400 meters from the Metropark Hotel.