I want to go to Panda Hotel from Macao by ferry. Which is the best route do you advise.

The ferry from Macau to HK will take you to HK-Macau Ferry Terminal or China Ferry Terminal.

If it is the former terminal, you can walk to Tsim Sha Tsui (TST) MTR Station to take Tsuen Wan Line to Tai Wo Hau Station. Get out from Exit B, you can walk to your hotel then by asking the local people or the hotel staff about the directions.

If you are arriving at Sheung Wan HK-Macao Ferry Terminal, you can take MTR Island Line to Admiralty Station. Then you can change to Tsuen Wan Line to tai Wo Hau, from where walk to your hotel.

Comparatively, it is easier to reach your hotel from China Ferry terminal, so when buying the ferry ticket, you can select the right one at a certain time.

As I know, the hotel provides shuttle buses between TST (DFS Galleria at Peking Road of TST) to Panda Hotel. So you can also contact the hotel in advance to reserve a seat. then upon your arrival at China Ferry Terminal, go to TST to take that to reach directly.