Usually, it is suggested that you take a bus from the Provincial Bus Station of Guangzhou to get to Zhuhai Gongbei Bus Station firstly. This bus is in operation from early morning until to 21:00 or 22:00 at the night. The journey is about 2 hours and takes you CNY65.

Then, you could walk to the Gongbei Port, located in walking-distance from the bus station. Go through the port, you will enter int Macau easily.

Much easier to take a direct (cross border) bus from the Landmark Canton Hotel in Haizhu Square. These operate every 15 minutes or so from around 7 am to 9 pm.