I reach Guangzhou South at 12am midnight, how to go hotel is in Tianhe North Shuiyin Road? how much?

Hey, it is best to go by taxi and it costs CNY80 or around. If you wanna use public transportation, catch overnight bus line 61 to Sports Center (Tiyu Zhongxin) with CNY4, and the last bus leaves at 01:00am. Then the distance to your hotel is 3km or so. Take a taxi to get at a cost of CNY10.