I arrive at 10:20 p.m. and needs to get into Garden Hotel, Guangzhou?

According to your arrival time, you can take subway line 3 to Jiahe Wanggang, change to line 2 to Railway Station and then change to line 5 to Taojin. Then walk southward about 300 yards to the hotel. But please note that most subway stop at around 23:00 to 23:30, so you need to hurry up.

If missing them, only taxi will be available. And it takes about CNY 100 at night.