what bus no that will direct to nathan road, imperial hotel in HK from macau ferry terminal?

Hi, Cristy. As I know, to your hotel, there is no direct bus from the ferry terminal and you need to transfer at once.
In my opinion, the local mtr is suggested to use.
From the terminal, you can walk to the Sheung Wan Station (Exit D) to take the Island Line to Admiralty Station and then change to the Tsuen Wan Line to Tsim Sha Tsui Station. Get out of the station from Exit E and then you can walk to your hotel easily.