Guangzhou Airport to Science City

Well, the airport shuttle bus will be still in service by then. But not a direct one can take you to the hotel. About the route, here is my suggestion:
You can take airport shuttle bus line 6 to the local East Railway Station first. It costs you CNY20. Upon arrival at the train station, you need transfer to bus Night No. 51 to Science Road (Kaitaidadao Lukou). After that, it is only about 1.5km from your hotel. So you can take a cab then. the fare of the bus and the taxi is about CNY12-14.