Arriving Guangzhou Airport at 16:30 best way to travel to Holiday Inn Shifu Guangzhou.

Hi，you can take airport shuttle bus line 5 and get off at Haizhu Plaza/Square. There you can transfer to bus no. 1, 268, 236, 219 or 57 and get off at Liu Er San Lu Station. After that, you can walk to the hotel in about 5 min.
Actually, upon your arrival at Haizhu Plaza, it is only about 3 km from your hotel, so you can take a taxi there very fast.