Which hotel is convenience to stay in Guangzhou?

I suggest you go to the downtown area to find a hotel to stay in, such as Haizhu Plaza area, The airport shuttle bus line 5 can take you there. The next day, you can catch the cross-border coach from Hiazhu Square to Macau. Or you can find a hotel near Guangdong Provincial Bus Station(near Guangzhou Railway Station), then take bus from this bus station to Gongbei, Zhuhai. Then passing through the border, you will get into Macau.