1.In the bus station beside Guangzhou Railway Station, there you can find bus to Gongbei(Macau is close to it), when arrive at Gongbei Port, pass the customs and you are at Macau. When go to downtown, you can take the free shuttle bus of Venetian Macau, it can send you to the hotel and you can go to other places from there.
The time period between you get on the bus and arrive at Macau would be 3 hours or less.

The city would not be very quiet in Spring Festival, but there would be several days that most people go home and get together with their families. Don't worry, many shops would open during this time, some celebrations would hold at that time.