No. There is only one train from Heifei to Guangzhou, Train K310. It takes nearly 18 hours.

Thank you so much Mr. John , Can I travel by the new Bullet from Hefei to Wuhan , then I change the line in Wuhan to Guangzhou . I only wish to take the new fast Bullet to save time , they told me it can take only 5 hours from Hefei to Wuhan then to Guangzhou .Thanks again

Well, if so, it is suggested that you take the train D3002/D3003 from Hefei to Wuhan Railway Station firstly. It runs from 10:08 to 12:21. An then, at Wuhan Railway Station, you could catch a high-speed train to arrive in Guangzhou in 3 hours.

Please note, there are three train stations in Wuhan (Wuhan Train Station, Hankou Train Station and Wuchang Train Station). However, all of the high-speed trains are departed from Wuhan Train Station to Guangzhou. Don't miss it!